Equine Studies

Effects of an articular cartilage lubrication with a viscosupplement in vitro and in vivo following osteochondral fractures in horses
Michelle M. Temple-Wong, PhD, Aimee R. Raleigh, PhD, David D. Frisbee, DVM, PhD, Robert L. Sah, MD, ScD, C. Wayne McIllwraith, BVSc, PhD
Dept. of Bioengineering & Institute of Engineering in Medicine-Center for Musculoskeletal Research: University of California-San Diego and Orthopeadic Research Center, C. Wayne Translational Research Center, College of Veterinary Medicine and Biomedical Services, Colorado State University.
Received: Sept 18, 2020
Accepted: Dec 17, 2020
Published: AJVR | Vol 82 | No. 8 | August 2021

Safety when used in horses:
Fred J. Caldwell, DVM, MS, DACVS, Earl M. Gaughan, DVM, DACVS, Melissa Fagerlin, BS BS Dept. of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36830
Safety Evaluation of Polyglycan® in Horses

Safety in horses when used at 1 & 3 times normal dose:
Safety Study on the Effects of Intra-articular Polyglycan at 1X and 3X Doses
CE Kawcak DVM, PhD, Diplomate ACVS Associate Professor, Equine Orthopaedic Research Laboratory, Colorado State University 10-14 08

Efficacy In horses with IA use:
Frisbie DD; Kawcak CE; McIlwraith CW; Werpy NM
Report on the Evaluation of Intra-Articular Polyglycan® for Osteoarthritis using an Equine Model
36th Annual Orthopedic Society Meeting, February 28 - March 6, 2009, Steamboat Springs, Colorado

Compared to other joint treatments:
David D. Frisbie, DVM, PhD, Diplomate ACVS, & ACVSMR Equine Orthopaedic Research Center, Department of Clinical Sciences, College of Veterinary Medicine and Biological Sciences, and Molecular, Cellular & Tissue Engineering, Colorado State University, Fort Collins, Colorado, 80523
Current Evidence on Treatments of Joint Disease
2nd Equine Lameness Research Workshop, Oklahoma City, OK July 24, 2012

Compared to controls in equine joints:
Christopher E. Kawcak, DVM, PhD, Dipl ACVS, C. Wayne McIlwraith, BVSc, PhD, DSc, FRCVS, Dipl ACVS, Gail Holmes Equine Orthopaedic Research Laboratory, Colorado State University, Fort Collins, CO
Comparison of Synovial Fluid in Middle Carpal Joints Undergoing Needle Aspiration, Infusion with Saline, and Infusion with a Combination of N-Acetyl-D-Glucosamine, Hyaluronic Acid, and Sodium Chondroitin Sulfate

Efficacy against single impact load:
Frances M. D., Henson, MA, Vet MB, PhD; Alan M. J. Getgood, MD; David M. Caborn, MD; C. Wayne McIlwraith, DVM, PhD, DSc; Neil Rushton,
Effect of a solution of hyaluronic acid–chondroitin sulfate–N-acetyl glucosamine on the repair response of cartilage to single-impact load damage
American Journal of Veterinary Research, February 2012, Vol. 73, No. 2, Pages 306-312 doi: 10.2460/ajvr.73.2.306

Companion Animal Studies

Safety in dogs, given IA or IM:
MacPhail CM, Brewer M, Hawley JR, Vier J, Lappin MR.
Local & systemic effect of a commercial preparation of CS, HA and NACD-glucosamine when administered IA or IM to healthy dogs
Proceedings of the American College of Veterinary Internal Medicine Annual Forum (abstract), New Orleans, LA June 1, 2012 (poster)